GLUR Rabbit Recombinant mAb Datasheet

生物描述

特异性	GLUR Rabbit Recombinant mAb detects endogenous level of total GLUR.
背景	Ionotropic glutamate receptor coassemble to form ligand-gated ion channels containing an agonist recognition site, a transmembrane ion permeation pathway, and gating elements that couple agonist-induced conformational changes to the opening or closing of the permeation pore. Glutamate receptors mediate fast excitatory synaptic transmission in the central nervous system and are localized on neuronal and non-neuronal cells. These receptors regulate a broad spectrum of processes in the brain, spinal cord, retina, and peripheral nervous system. The glutamate receptors assemble as tetrameric complexes of subunits, and functional receptors are formed exclusively by assembly of subunits within the same functional receptor class. Glutamate receptors are grouped into four distinct classes based on pharmacology and structural homology, including the AMPA receptors (GluA1-GluA4), the kainate receptors (GluK1-GluK5), the NMDA receptors (GluN1, GluN2A-GluN2D, GluN3A, and GluN3B), and the δ receptors (GluD1 and GluD2). This class of receptors has also been shown to be involved in many diverse neuropathologies, such as ischemia, Parkinson's disease, and amyotrophic lateral sclerosis, and to play other varying roles throughout the body.

特异性

GLUR Rabbit Recombinant mAb detects endogenous level of total GLUR.

背景

Ionotropic glutamate receptor coassemble to form ligand-gated ion channels containing an agonist recognition site, a transmembrane ion permeation pathway, and gating elements that couple agonist-induced conformational changes to the opening or closing of the permeation pore. Glutamate receptors mediate fast excitatory synaptic transmission in the central nervous system and are localized on neuronal and non-neuronal cells. These receptors regulate a broad spectrum of processes in the brain, spinal cord, retina, and peripheral nervous system. The glutamate receptors assemble as tetrameric complexes of subunits, and functional receptors are formed exclusively by assembly of subunits within the same functional receptor class. Glutamate receptors are grouped into four distinct classes based on pharmacology and structural homology, including the AMPA receptors (GluA1-GluA4), the kainate receptors (GluK1-GluK5), the NMDA receptors (GluN1, GluN2A-GluN2D, GluN3A, and GluN3B), and the δ receptors (GluD1 and GluD2). This class of receptors has also been shown to be involved in many diverse neuropathologies, such as ischemia, Parkinson's disease, and amyotrophic lateral sclerosis, and to play other varying roles throughout the body.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

56kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck