生物描述

特异性

GluR1 Rabbit Recombinant mAb detects endogenous levels of total GluR1.

背景

Glutamate receptor (GluRs) are important in neural plasticity, neural development, and neurodegeneration. Activation of GluRs mediate a large number of neuronal processes such as long-term potentiation and ischemic damage. Two classes of GluRs have been characterized: ionotropic (iGluRs) and metabotropic (mGluRs). They both bind to Glu, and Glu binding can influence the permeability of ion channels. The iGluRs are ligand-gated ion channels that mediate the vast majority of excitatory neurotransmission in the brain. The iGluR family is classified into three major subtypes: NMDA, AMPA and kainate (Ka) receptors. AMPA family is composed of GluR 1-4 (GluRA-D). AMPA receptors are involved in mediating most forms of fast glutamatergic neurotransmission, which corresponds to a Ca2+ influx. GluR1 has several identified phosphorylation sites on the intracellular carboxy terminus: serine (S) 818, S831, threonine (T) 840, and S845.

使用信息

抗体应用	WB, IHC,ELISA,ELISA
稀释比例	WB IHC 1:1000 1:50
反应性	Human Mouse Rat
MW (kDa)	102kDa
抗体类型
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Colin G Rousseaux. J Toxicol Pathol. 2008, 21: 25-51. [2] Lee HK, et al. J Neurophysiol. 2010, 103(1):479-89.

Application Data

WB

IHC