Glypican 3 Rabbit Recombinant mAb Datasheet

生物描述

特异性	Glypican 3 Rabbit Recombinant mAb detects endogenous level of total Glypican 3.
背景	Glypican-3 (GPC-3) is a membrane anchored heparin sulfate proteoglycan normally expressed in fetal liver and placenta, but not in normal adult liver. Glypicans are bound to the outer surface of the plasma membrane by a glycosylphosphatidylinositol anchor. In addition, they can be found in the extracellular environment after being released by a lipase called Notum. GPC3 is widely expressed during development, but it is downregulated in most adult tissues. This glypican plays an important role in the regulation of cell proliferation in the developing bone via mediation of the Hh signaling pathway. GPC3 also stimulates HCC growth by promoting canonical Wnt signaling.

特异性

Glypican 3 Rabbit Recombinant mAb detects endogenous level of total Glypican 3.

背景

Glypican-3 (GPC-3) is a membrane anchored heparin sulfate proteoglycan normally expressed in fetal liver and placenta, but not in normal adult liver. Glypicans are bound to the outer surface of the plasma membrane by a glycosylphosphatidylinositol anchor. In addition, they can be found in the extracellular environment after being released by a lipase called Notum. GPC3 is widely expressed during development, but it is downregulated in most adult tissues. This glypican plays an important role in the regulation of cell proliferation in the developing bone via mediation of the Hh signaling pathway. GPC3 also stimulates HCC growth by promoting canonical Wnt signaling.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human

MW (kDa)

66kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck