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别名 | N/A | 储存条件 (自收到货起) |
3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂 |
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化学式 | C17H13N3O |
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分子量 | 275.3 | CAS号 | 504433-23-2 | ||||||||||||
Solubility (25°C)* | 体外 | DMSO | 27.5 mg/mL (99.89 mM) | ||||||||||||
Water | Insoluble | ||||||||||||||
Ethanol | Insoluble | ||||||||||||||
体内(现配现用) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | GW441756 是一种有效的,选择性的TrkA抑制剂,IC50为2 nM,对c-Raf1和CDK2几乎没有抑制活性。GW441756 可增加caspase-3并诱导凋亡。 | ||
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靶点 |
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体外研究 | GW441756能够以计量依赖的方式特异性阻断TrkA诱导的细胞死亡。GW441756能够阻断TrkA介导的γH2AX产生[2]和TrkA过表达细胞的细胞凋亡。[3] |
数据来源于[Data independently produced by , , Exp Neurol, 2018, 300:87-99]
数据来源于[Data independently produced by , , Mol Cell Neurosci, 2016, 77:11-20.]
数据来源于[Data independently produced by , , Int J Mol Med, 2018, 42(3):1484-1494]
Androgens and NGF Mediate the Neurite-Outgrowth through Inactivation of RhoA [ Cells, 2023, 12(3)373] | PubMed: 36766714 |
Androgens and NGF Mediate the Neurite-Outgrowth through Inactivation of RhoA. Cells 2023, 12, 373 [ Cells, 2023, 12(3):373] | PubMed: None |
The effect of Banxia-houpo decoction on CUMS-induced depression by promoting M2 microglia polarization via TrkA/Akt signalling [ J Cell Mol Med, 2023, 10.1111/jcmm.17906] | PubMed: 37581474 |
Huntingtin-associated protein 1 ameliorates neurological function rehabilitation by facilitating neurite elongation through TrKA-MAPK pathway in mice spinal cord injury [ Front Mol Neurosci, 2023, 16:1214150] | PubMed: 37609072 |
Huntingtin-associated protein 1 ameliorates neurological function rehabilitation by facilitating neurite elongation through TrKA-MAPK pathway in mice spinal cord injury [ Front Mol Neurosci, 2023, 16:1214150] | PubMed: 37609072 |
Wogonin, a Bioactive Ingredient from Huangqi Guizhi Formula, Alleviates Discogenic Low Back Pain via Suppressing the Overexpressed NGF in Intervertebral Discs [ Mediators Inflamm, 2023, 2023:4436587] | PubMed: 36860203 |
Propionibacterium acnes contributes to low back pain via upregulation of NGF in TLR2-NF-κB/JNK or ROS pathway [ Microbes Infect, 2022, S1286-4579(22)00050-8] | PubMed: 35430372 |
Sea urchin gangliosides exhibit neuritogenic effects in neuronal PC12 cells via TrkA- and TrkB-related pathways [ Biosci Biotechnol Biochem, 2021, 85(3):675-686] | PubMed: 33589896 |
Nerve growth factor activates autophagy in Schwann cells to enhance myelin debris clearance and to expedite nerve regeneration. [ Theranostics, 2020, 10(4):1649-1677] | PubMed: 32042328 |
Activation of receptor tyrosine kinases mediates acquired resistance to MEK inhibition in malignant peripheral nerve sheath tumors [ Cancer Res, 2020, canres.1992.2020] | PubMed: 33203698 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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