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别名 | N/A | 储存条件 (自收到货起) |
3年 -20°C 粉状 | ||||
化学式 | C17H17N3O |
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分子量 | 279.34 | CAS号 | 941987-60-6 | ||||
Solubility (25°C)* | 体外 | DMSO | 56 mg/mL (200.47 mM) | ||||
Ethanol | 14 mg/mL (50.11 mM) | ||||||
Water | Insoluble | ||||||
体内(现配现用) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | H-151是STING的共价拮抗剂,在人细胞和体内均具有显著的抑制活性。 | |
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Inhibiting autophagy enhanced mitotic catastrophe-mediated anticancer immune responses by regulating the cGAS-STING pathway [ Cancer Lett, 2024, 586:216695] | PubMed: 38325769 |
Galectin-9 blockade synergizes with ATM inhibition to induce potent anti-tumor immunity [ Int J Biol Sci, 2023, 19(3):981-993] | PubMed: 36778120 |
mascRNA alleviates STING-TBK1 signaling-mediated immune response through promoting ubiquitination of STING [ Mol Immunol, 2023, 154:45-53] | PubMed: 36603304 |
BAP1 maintains HIF-dependent interferon beta induction to suppress tumor growth in clear cell renal cell carcinoma [ Cancer Lett, 2022, 547:215885] | PubMed: 35995140 |
Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation [ Cell Rep, 2022, 41-1:111434] | PubMed: 36198273 |
WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC [ Cell Rep, 2022, 39(7):110814] | PubMed: 35584676 |
Manganese induces tumor cell ferroptosis through type-I IFN dependent inhibition of mitochondrial dihydroorotate dehydrogenase [ Free Radic Biol Med, 2022, 193(Pt 1):202-212] | PubMed: 36228830 |
SHP-1 knockdown suppresses mitochondrial biogenesis and aggravates mitochondria-dependent apoptosis induced by all trans retinal through the STING/AMPK pathways [ Mol Med, 2022, 28(1):125] | PubMed: 36273174 |
AKT1 Is Required for a Complete Palbociclib-Induced Senescence Phenotype in BRAF-V600E-Driven Human Melanoma [ Cancers (Basel), 2022, 14(3)572] | PubMed: 35158840 |
Pharmacological activation of STING blocks SARS-CoV-2 infection [ Sci Immunol, 2021, 6(59)eabi9007] | PubMed: 34010142 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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