MEK7 Rabbit Recombinant mAb

生物描述

特异性

HDAC10 Rabbit Recombinant mAb detects endogenous level of total HDAC10.

背景

Histone deacetylases (HDACs) are the enzymes responsible for the removal of acetyl groups from acetylated histone and non-histone proteins. Known mammalian HDACs are grouped into three classes: Class I consists of HDAC1, HDAC2, HDAC3 and HDAC8. These HDACs show significant sequence similarity to yeast Rpd3p. Class II members include HDAC4, HDAC5, HDAC6, HDAC7 and HDAC9. They possess catalytic domains with significant sequence homology to the N-terminal half of yeast Hda1p. Class III comprises proteins with catalytic domains similar to that of the yeast NAD+-dependent deacetylase Sir2p. While class I deacetylases function as transcriptional co-repressors, Sir2p-related proteins appear to be involved in gene silencing. HDAC10 is a novel class II deacetylase that is enriched in the cytoplasm and widely expressed in human tissues and cultured mammalian cells. It is able to repress transcription and interacts with HDAC3.

使用信息

抗体应用	WB, IF,ELISA,ELISA
稀释比例	WB IF 1:1000 1:50
反应性	Human Mouse
MW (kDa)	75kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Tong JJ, et al. Nucleic Acids Res. 2002, 30(5):1114-23. [2] Hai Y, et al. Nat Commun. 2017, 8:15368.

Application Data

WB

IF