HDAC11 Rabbit Recombinant mAb Datasheet

生物描述

特异性	HDAC11 Rabbit Recombinant mAb detects endogenous level of HDAC11.
背景	HDAC11 is a novel and unique member of the histone deacetylase family. HDAC11 and HDAC6 are present in common multiprotein complexes. HDAC11 is a predominantly nuclear protein. Furthermore, the HDAC11 mRNA is abundantly expressed in specific normal human tissues as well as several cancer cell lines. HDAC11 and HDAC6 can interact at the same time with the Vitamin D3 Receptor (VDR) to regulate the expression of MYC. Endogenous HDAC6 and HDAC11 physically interact with each other in the cytoplasm and nuclei of APCs and are recruited to the IL-10 gene promoter to regulate its transcriptional activity.

特异性

HDAC11 Rabbit Recombinant mAb detects endogenous level of HDAC11.

背景

HDAC11 is a novel and unique member of the histone deacetylase family. HDAC11 and HDAC6 are present in common multiprotein complexes. HDAC11 is a predominantly nuclear protein. Furthermore, the HDAC11 mRNA is abundantly expressed in specific normal human tissues as well as several cancer cell lines. HDAC11 and HDAC6 can interact at the same time with the Vitamin D3 Receptor (VDR) to regulate the expression of MYC. Endogenous HDAC6 and HDAC11 physically interact with each other in the cytoplasm and nuclei of APCs and are recruited to the IL-10 gene promoter to regulate its transcriptional activity.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human

MW (kDa)

39kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck