HDAC8 Rabbit Recombinant mAb Datasheet

生物描述

特异性	HDAC8 Rabbit Recombinant mAb detects endogenous level of total HDAC8.
背景	HDACs are "eraser" enzymes that cleave acetate from acetylated ɛ-amino groups of lysines in histones and other proteins. Deacetylation of histones causes global chromatin condensation and transcription repression. HDACs participate in critical signaling networks and their deregulation has been linked to many diseases. Histone deacetylase 8 (HDAC8) is a class I histone deacetylase implicated as a therapeutic target in various diseases, including cancer, X-linked intellectual disability, and parasitic infections.

特异性

HDAC8 Rabbit Recombinant mAb detects endogenous level of total HDAC8.

背景

HDACs are "eraser" enzymes that cleave acetate from acetylated ɛ-amino groups of lysines in histones and other proteins. Deacetylation of histones causes global chromatin condensation and transcription repression. HDACs participate in critical signaling networks and their deregulation has been linked to many diseases. Histone deacetylase 8 (HDAC8) is a class I histone deacetylase implicated as a therapeutic target in various diseases, including cancer, X-linked intellectual disability, and parasitic infections.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

42kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Chakrabarti A, et al. Trends Pharmacol Sci. 2015, 36(7):481-92.

Application Data

WB

Validated by Selleck