Histone H2A.Z Rabbit Recombinant mAb

生物描述

特异性

Histone H2A.Z Rabbit Recombinant mAb detects endogenous level of total Histone H2A.Z.

背景

Gene regulatory programs in different cell types are largely defined through cell-specific enhancers activity. H2A.Z is the histone variant that has been shown to play important roles in transcription mainly by controlling proximal promoters. It is used to mediate the thermosensory response, and is essential to perceive the ambient temperature. H2A.Z has been implicated in many diverse biological processes, such as gene activation, chromosome segregation, heterochromatin silencing, and progression through the cell cycle. The involvement of H2A.Z in transcription regulation and in maintaining chromosome stability and segregation may be relevant to a recently recognized connection to oncogenesis. Indeed, studies in cancer patients have reported significant overexpression of H2A.Z in several major types of malignancies, especially at the metastatic stage.

使用信息

抗体应用	WB, IHC, IF,ELISA,ELISA
稀释比例	WB IHC IF 1:1000 1:50 1:50
反应性	Human Mouse Rat
MW (kDa)	13kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Brunelle M, et al. Nucleic Acids Res. 2015, 43(20):9742-56. [2] El Kharroubi A, et al. Mol Cell Biol. 1998, 18(5):2535-44. [3] Zlatanova J, et al. Structure. 2008, 16(2):166-79.

Application Data

WB

IHC

IF