Datasheet

生物描述

特异性	Histone H4 (acetyl K5) Rabbit Recombinant mAb detects endogenous levels of Histone H4 (acetyl K5).
背景	Histone modifications play crucial roles in genome regulation with lysine acetylation being implicated in transcriptional control. The N-terminal tail of histone H4 has four acetylated lysines: K5, K8, K12, and K16. Of these, only K16 is strongly associated with a specific regulatory function in yeast, where its acetylation state regulates the extent of silent heterochromatin. K5, K8, and K12 are partially redundant. H4-dependent histone deposition requires at least one of K5, K8, or K12. H4 specifically diacetylated at lysines 5 and 12 is involved in post-replication chromatin assembly

特异性

Histone H4 (acetyl K5) Rabbit Recombinant mAb detects endogenous levels of Histone H4 (acetyl K5).

背景

Histone modifications play crucial roles in genome regulation with lysine acetylation being implicated in transcriptional control. The N-terminal tail of histone H4 has four acetylated lysines: K5, K8, K12, and K16. Of these, only K16 is strongly associated with a specific regulatory function in yeast, where its acetylation state regulates the extent of silent heterochromatin. K5, K8, and K12 are partially redundant. H4-dependent histone deposition requires at least one of K5, K8, or K12. H4 specifically diacetylated at lysines 5 and 12 is involved in post-replication chromatin assembly

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

11kDa

抗体类型

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck