Histone H4 (mono methyl K16) Rabbit Recombinant mAb Datasheet

生物描述

特异性	Histone H4 (mono methyl K16) Rabbit Recombinant mAb detects endogenous levels of total Histone H4 (mono methyl K16).
背景	Histone H4 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Histone proteins are highly post-translationally modified. Covalently bonded modifications include acetylation and methylation of the N-terminal tails. These modifications may alter expression of genes located on DNA associated with its parent histone octamer. Histone methylation occurs on arginine, lysine and histidine amino acids residues. Mono-, di- or tri-methylation has been discovered on histone H2A, H3 and H4. Histone methylation has been associated with various cellular functions such as transcription, DNA replication, and DNA damage response including repair, heterochromatin formation, and somatic cell reprogramming. Histone Lys methylation plays an important role in determining chromatin states and is mostly catalyzed by SET domain-containing proteins.

特异性

Histone H4 (mono methyl K16) Rabbit Recombinant mAb detects endogenous levels of total Histone H4 (mono methyl K16).

背景

Histone H4 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Histone proteins are highly post-translationally modified. Covalently bonded modifications include acetylation and methylation of the N-terminal tails. These modifications may alter expression of genes located on DNA associated with its parent histone octamer. Histone methylation occurs on arginine, lysine and histidine amino acids residues. Mono-, di- or tri-methylation has been discovered on histone H2A, H3 and H4. Histone methylation has been associated with various cellular functions such as transcription, DNA replication, and DNA damage response including repair, heterochromatin formation, and somatic cell reprogramming. Histone Lys methylation plays an important role in determining chromatin states and is mostly catalyzed by SET domain-containing proteins.

使用信息

抗体应用

IF,ELISA,ELISA

稀释比例

IF

1:500

反应性

Human Mouse

MW (kDa)

11kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Bhasin M, et al. J Comput Biol. 2006, 13(1):102-12.

Application Data

IF

Validated by Selleck