HMGCR Rabbit Recombinant mAb Datasheet

生物描述

特异性	HMGCR Rabbit Recombinant mAb detects endogenous level of total HMGCR.
背景	HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, officially abbreviated HMGCR), a transmembrane glycoprotein, is the rate-controlling enzyme of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. HMG-CoA reductase is anchored in the membrane of the endoplasmic reticulum. Its activity is tightly regulated to ensure maintenance of lipid homeostasis, disruption of which is a major cause of human morbidity and mortality. HMGCR regulation takes place at the levels of transcription, translation, post-translational modification and degradation.

特异性

HMGCR Rabbit Recombinant mAb detects endogenous level of total HMGCR.

背景

HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, officially abbreviated HMGCR), a transmembrane glycoprotein, is the rate-controlling enzyme of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. HMG-CoA reductase is anchored in the membrane of the endoplasmic reticulum. Its activity is tightly regulated to ensure maintenance of lipid homeostasis, disruption of which is a major cause of human morbidity and mortality. HMGCR regulation takes place at the levels of transcription, translation, post-translational modification and degradation.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

97kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck