Homoharringtonine (HHT)

目录号：S9015 批次号：S901504

化学数据

	别名	CGX-635, Omacetaxine mepesuccinate, Myelostat, NSC 141633	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₂₉H₃₉NO₉
	分子量	545.62	CAS号	26833-87-4
Solubility (25°C)*	体外	DMSO	100 mg/mL (183.27 mM)
		Ethanol	100 mg/mL (183.27 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述	Homoharringtonine (HHT)是一种具有抗肿瘤特性的植物生物碱，通过与核糖体A位点的相互作用阻止蛋白质合成的初始延伸步骤，从而抑制蛋白质的翻译。Homoharringtonine可逆地抑制IL-6诱导的STAT3酪氨酸705磷酸化和减少抗凋亡蛋白的表达。

参考文献

Homoharringtonine (HHT)在文献中得到引用

USP36 stabilizes nucleolar Snail1 to promote ribosome biogenesis and cancer cell survival upon ribotoxic stress [ Nat Commun, 2023, 14(1):6473]	PubMed: 37833415
USP36 stabilizes nucleolar Snail1 to promote ribosome biogenesis and cancer cell survival upon ribotoxic stress [ Nat Commun, 2023, 14(1):6473]	PubMed: 37833415
TIAR and FMRP shape pro-survival nascent proteome of leukemia cells in the bone marrow microenvironment [ iScience, 2023, 26(4):106543]	PubMed: 37123244
Follicular lymphoma-associated mutations in the V-ATPase chaperone VMA21 activate autophagy creating a targetable dependency [ Autophagy, 2022, 1-19]	PubMed: 35287545
The therapeutic effect of KSP inhibitors in preclinical models of cholangiocarcinoma [ Cell Death Dis, 2022, 13-9:799]	PubMed: 36123339
A survey of optimal strategy for signature-based drug repositioning and an application to liver cancer [ Elife, 2022, 11e71880]	PubMed: 35191375
SiCoDEA: A Simple, Fast and Complete App for Analyzing the Effect of Individual Drugs and Their Combinations [ Biomolecules, 2022, 12(7)904]	PubMed: 35883460
Establishment and Characterization of NCC-PMP1-C1: A Novel Patient-Derived Cell Line of Metastatic Pseudomyxoma Peritonei [ J Pers Med, 2022, 12(2)258]	PubMed: 35207746
Homoharringtonine Attenuates Dextran Sulfate Sodium-Induced Colitis by Inhibiting NF-κB Signaling [ Mediators Inflamm, 2022, 2022:3441357]	PubMed: 36211988
Establishment and characterization of NCC-UPS4-C1: a novel cell line of undifferentiated pleomorphic sarcoma from a patient with Li-Fraumeni syndrome [ Hum Cell, 2022, 10.1007/s13577-022-00671-y]	PubMed: 35118583

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如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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