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特异性 | HSPA14 Rabbit Recombinant mAb detects endogenous level of total HSPA14. |
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背景 | Heat shock proteins (HSPs) are ubiquitous proteins found in plant and animal cells. HSPs functioning as molecular chaperones are the key components responsible for protein folding, assembly, translocation, and degradation under stress conditions and in many normal cellular processes. In plants and animals, there are five major families of HSPs conservatively recognized as molecular chaperones based on their approximate molecular weights, such as HSP100, HSP90, HSP70, HSP60, and small HSP (sHSP). The HSP70 family represents one of the most highly conserved classes of heat shock proteins. HSP70-like protein 1 (HSP70L1, also HSPA14) belongs to the HSP70 family, which contains at least 11 members with distinct intracellular locations and functions. HSPA14 within cells is one component of mammalian ribosome-associated complex (mRAC) binding to the ribosome. Intrinsic HSPA14 inhibits the activation of the STAT1 pathway as well as the STAT3 pathway, and in fact also inhibits the maturation of dendritic cells. |
抗体应用 | WB, IHC, IF,ELISA,ELISA | ||||||
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稀释比例 |
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反应性 | Human Mouse Rat | ||||||
MW (kDa) | 55kDa | ||||||
抗体类型 | Rabbit | ||||||
储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||||||
储存条件 (自收到货起) |
Store at –20°C. |
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WB
Validated by Selleck
IHC
Validated by Selleck
IF
Validated by Selleck