HTRA2 Rabbit Recombinant mAb Datasheet

生物描述

特异性	HTRA2 Rabbit Recombinant mAb detects endogenous level of total HTRA2.
背景	High-temperature requirement protein A2 (HtrA2) is a a serine protease that localizes in the mitochondria. It is involved in mitochondrial homeostasis and regulation of cellular apoptosis. HtrA1, 3 and 4 are most likely targeted to the secretory pathway, whereas HtrA2/Omi resides in the mitochondrial intermembrane space (IMS). In response to various cellular stresses, HtrA2 is processed to Δ133 mature HtrA2 and released into the cytosol. The released cytosolic mature HtrA2 promotes cell death through its serine protease activity via either a caspase-dependent or a caspase-independent mechanism.

特异性

HTRA2 Rabbit Recombinant mAb detects endogenous level of total HTRA2.

背景

High-temperature requirement protein A2 (HtrA2) is a a serine protease that localizes in the mitochondria. It is involved in mitochondrial homeostasis and regulation of cellular apoptosis. HtrA1, 3 and 4 are most likely targeted to the secretory pathway, whereas HtrA2/Omi resides in the mitochondrial intermembrane space (IMS). In response to various cellular stresses, HtrA2 is processed to Δ133 mature HtrA2 and released into the cytosol. The released cytosolic mature HtrA2 promotes cell death through its serine protease activity via either a caspase-dependent or a caspase-independent mechanism.

使用信息

抗体应用

WB ,ELISA,ELISA

稀释比例

WB

1:500

反应性

Human Mouse Rat

MW (kDa)

38kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Goo HG, et al. Biochim Biophys Acta. 2013, 1833(8):1866-75.

Application Data

WB

Validated by Selleck