Hydroxychloroquine (HCQ) Sulfate

目录号：S4430 批次号：S443010

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化学数据

化学结构式 别名 NSC 4375 储存条件
(自收到货起)		 3年 / -20°C / 粉状
1年 / -80°C / 溶于溶剂
化学式

C18H28ClN3O5S
分子量 433.95 CAS号 747-36-4
Solubility (25°C)* 体外 Water 87 mg/mL (200.48 mM)
DMSO Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述 Hydroxychloroquine (HCQ) Sulfate是一种抗疟疾药，用于治疗系统性红斑狼疮，类风湿关节炎等自身免疫病，炎症以及皮肤病。它也是autophagy和toll-like receptor (TLR) 7/9的抑制剂。
靶点
TLR9 [5] Autophagy [1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

客户使用selleck产品的实验数据

数据来源于[Data independently produced by , , Clin Cancer Res, 2018, doi:10.1158/1078-0432.CCR-18-1489]

数据来源于[Data independently produced by , , J Exp Clin Cancer Res, 2018, 37(1):272]

数据来源于[Data independently produced by , , Cell Death Dis, 2017, 8(1):e2558]

数据来源于[Data independently produced by , , Oxid Med Cell Longev, 2017, 8519169]

Hydroxychloroquine (HCQ) Sulfate在文献中得到引用

MYC Overexpression Enhances Sensitivity to MEK Inhibition in Head and Neck Squamous Cell Carcinoma [ Int J Mol Sci, 2025, 26(2)588] PubMed: 39859304
TRIM22 inhibits the metastasis of colorectal cancer through facilitating β-Catenin degradation [ Exp Cell Res, 2025, 446(2):114473] PubMed: 39978715
Itaconate drives pro-inflammatory responses through proteasomal degradation of GLO1 [ Biochem Biophys Res Commun, 2025, 747:151292] PubMed: 39787788
Inhibition of ethanol-induced eNAMPT secretion attenuates liver ferroptosis through BAT-Liver communication [ Redox Biol, 2024, 75:103274] PubMed: 39059204
Acetylation of MOB1 mediates polyphyllin II-reduced lysosome biogenesis in breast cancer by promoting the cytoplasmic retention of the YAP/TFEB coactivator complex [ Phytomedicine, 2024, 10.1016/j.phymed.2023.155152] PubMed: 37922793
Small molecule inhibitor targeting the Hsp70-Bim protein-protein interaction in estrogen receptor-positive breast cancer overcomes tamoxifen resistance [ Breast Cancer Res, 2024, 26(1):33] PubMed: 38409088
ATG7/GAPLINC/IRF3 axis plays a critical role in regulating pathogenesis of influenza A virus [ PLoS Pathog, 2024, 20(1):e1011958] PubMed: 38227600
Mechanical forces inducing oxaliplatin resistance in pancreatic cancer can be targeted by autophagy inhibition [ Commun Biol, 2024, 7(1):1581] PubMed: 39604540
Ciprofloxacin is a novel anti-ferroptotic antibiotic [ Heliyon, 2024, 10(11):e32571] PubMed: 38961954
ALKBH5 modulation of ferroptosis in recurrent miscarriage: implications in cytotrophoblast dysfunction [ PeerJ, 2024, 12:e18227] PubMed: 39434797

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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