IFNAR1 Rabbit Recombinant mAb Datasheet

生物描述

特异性	IFNAR1 Rabbit Recombinant mAb detects endogenous level of total IFNAR1.
背景	The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. Type I IFN receptor forms a ternary complex, composed of its two subunits IFNAR1 and IFNAR2, and a type I IFN ligand. IFNAR1 is the low affinity subunit. Its cytoplasmic domain associates with Tyk2 and Tyk2 is required for membrane expression of IFNAR1. In the absence of Tyk2, a cytoplasmic IFNAR1 motif is phosphorylated, inducing receptor internalization. IFNAR1 then localizes to the perinuclear endosomal compartment and is degraded. IFNAR1 binding to low affinity ligands, such as IFNα subtypes, has been proposed to be the rate limiting step in the ternary complex formation.

特异性

IFNAR1 Rabbit Recombinant mAb detects endogenous level of total IFNAR1.

背景

The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. Type I IFN receptor forms a ternary complex, composed of its two subunits IFNAR1 and IFNAR2, and a type I IFN ligand. IFNAR1 is the low affinity subunit. Its cytoplasmic domain associates with Tyk2 and Tyk2 is required for membrane expression of IFNAR1. In the absence of Tyk2, a cytoplasmic IFNAR1 motif is phosphorylated, inducing receptor internalization. IFNAR1 then localizes to the perinuclear endosomal compartment and is degraded. IFNAR1 binding to low affinity ligands, such as IFNα subtypes, has been proposed to be the rate limiting step in the ternary complex formation.

使用信息

抗体应用

WB ,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human

MW (kDa)

90,130kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck