IKB epsilon Rabbit Recombinant mAb

生物描述

特异性

IKB epsilon Rabbit Recombinant mAb detects endogenous level of total IKB epsilon.

背景

Members of the nuclear factor of kappa B (NF-κB) transcription factor family, p50, p52, p65 (RelA), c-Rel and RelB, are maintained as inactive homo- or heterodimers in the cytoplasm by inhibitors of kappa B (IκBs). IκB degradation permits nuclear translocation of NF-κB and induction of genes responsible for many cellular responses including inflammation, survival and differentiation. IκBε differs from IκBs -α and -β structurally. IκBα tends to bind p65/p50, while IκBs-ε and -β prefer c-Rel and p65. IκBε is expressed in T and B lymphocytes. It regulates genes transactivated by heterodimers of c-Rel and homodimers of RelA. Functionally, IκBε and IκBα both contribute to post-induction repression of transcription by removing NF-κB from the nucleus.

使用信息

抗体应用	WB, IHC,ELISA,ELISA
稀释比例	WB IHC 1:1000 1:50
反应性	Human
MW (kDa)	45kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Clark JM, et al. PLoS One. 2011, 6(9):e24504.

Application Data

WB

IHC