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别名 | NLG-8189, 1-Methyl-D-tryptophan, 1-MT | 储存条件 (自收到货起) |
3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂 |
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化学式 | C12H14N2O2 |
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分子量 | 218.25 | CAS号 | 110117-83-4 | |
Solubility (25°C)* | 体外 | 0.1M NaOH | 11 mg/mL (50.4 mM) | |
DMSO | 1 mg/mL (4.58 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | Indoximod是甲基化的色氨酸,作为 IDO (吲哚胺-(2,3)-双加氧酶) 通路抑制剂能够逆转IDO介导的免疫抑制。Phase 2。此产品溶解度不佳,动物实验可用,细胞实验请谨慎选择! | |
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靶点 |
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体外研究 | Indoximod显著逆转表达IDO的树突细胞产生的T细胞抑制,使用人单核细胞衍生的树突细胞和直接分离于肿瘤引流淋巴结的小鼠树突细胞。[1] Indoximod激活Trp充足信号而刺激mTOR,并解除IDO诱导的Trp缺乏和自体吞噬响应。[2] |
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体内研究 | 在移植的黑色素瘤和移植的原生乳腺癌小鼠模型中,Indoximod (400 mg/kg p.o.) 结合化学免疫疗法增强抗肿瘤免疫力。[1] |
动物实验 | 动物模型 | 小鼠 B16F10 和 4T1 肿瘤模型 |
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剂量 | 400 mg/kg | |
给药处理 | p.o. |
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Host-functionalization of macrin nanoparticles to enable drug loading and control tumor-associated macrophage phenotype [ Front Immunol, 2024, 15:1331480] | PubMed: 38545103 |
Bridging of host-microbiota tryptophan partitioning by the serotonin pathway in fungal pneumonia [ Nat Commun, 2023, 14(1):5753] | PubMed: 37717018 |
Bridging of host-microbiota tryptophan partitioning by the serotonin pathway in fungal pneumonia [ Nat Commun, 2023, 14(1):5753] | PubMed: 37717018 |
Tryptophan potentiates CD8+ T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation [ J Immunother Cancer, 2021, 9(7)e002840] | PubMed: 34326168 |
Indoleamine 2, 3-dioxygenase 1 aggravates acetaminophen-induced acute liver failure by triggering excess nitroxidative stress and iron accumulation [ Free Radic Biol Med, 2021, S0891-5849(21)00407-X] | PubMed: 34242792 |
Decreased IDO1 Dependent Tryptophan Metabolism in Aged Lung during Influenza [ Eur Respir J, 2020, 2000443] | PubMed: 33243840 |
A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer [ Elife, 2020, 9e56749] | PubMed: 33016874 |
Early myeloid-derived suppressor cells (HLA-DR-/lowCD33+CD16-) expanded by granulocyte colony-stimulating factor prevent acute graft-versus-host disease (GVHD) in humanized mouse and might contribute to lower GVHD in patients post allo-HSCT. [ J Hematol Oncol, 2019, 12(1):31] | PubMed: 30885244 |
TLR7/8-agonist-loaded Nanoparticles Promote the Polarization of Tumour-Associated Macrophages to Enhance Cancer Immunotherapy [ Nat Biomed Eng, 2018, 2(8):578-588] | PubMed: 31015631 |
Synthesis and biological evaluation of new berberine derivatives as cancer immunotherapy agents through targeting IDO1. [ Eur J Med Chem, 2018, 143:1858-1868] | PubMed: 29133053 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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