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别名 | INK 128,TAK-228 | 储存条件 (自收到货起) |
3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂 |
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化学式 | C15H15N7O |
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分子量 | 309.33 | CAS号 | 1224844-38-5 | |
Solubility (25°C)* | 体外 | DMSO | 62 mg/mL (200.43 mM) | |
Ethanol | 2 mg/mL (6.46 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | Sapanisertib (MLN0128, INK 128, TAK-228) 是一种有效的,选择性mTOR抑制剂,在无细胞试验中IC50为1 nM;对I型PI3K亚型的作用效果低200倍以上,与Rapamycin相比,优先抑制mTORC1/2,且对促侵袭基因敏感。Phase 1。 | |||||||||||
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靶点 |
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体外研究 | INK 128 表现对mTOR酶的抑制活性并对PI3K激酶的选择性超过100倍。[1] 作为TORC1/2抑制剂,INK 128抑制TORC1的下游底物S6和4EBP1的磷酸化。此外,INK 128也显示了对雷帕霉素和泛PI3K抑制剂耐受的细胞株的有效抑制效应。[2] |
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体内研究 | 在ZR-75-1乳腺癌异种移植模型中,INK 128(0.3 mg/kg/day)的处理表现了肿瘤生长抑制效果。[1] 在多种移植体模型中,每日口服给药INK 128抑制血管生成和肿瘤生长。[2] |
数据来源于[Data independently produced by Biochem Biophys Res Commun, 2013, 440(4), 701-6]
, Antonino Maria Spart from University of Bologn
数据来源于[Data independently produced by , , Hepatology, 2017, 66(6):1920-1933]
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Histopathologic and proteogenomic heterogeneity reveals features of clear cell renal cell carcinoma aggressiveness [ Cancer Cell, 2023, 41(1):139-163.e17] | PubMed: 36563681 |
mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching [ Cell Rep, 2023, 42(8):112868] | PubMed: 37494188 |
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BMAL1/p53 mediating bronchial epithelial cell autophagy contributes to PM2.5-aggravated asthma [ Cell Commun Signal, 2023, 21(1):39] | PubMed: 36803515 |
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Identification and subsequent validation of transcriptomic signature associated with metabolic status in endometrial cancer [ Sci Rep, 2023, 13(1):13763] | PubMed: 37612452 |
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Identification and subsequent validation of transcriptomic signature associated with metabolic status in endometrial cancer [ Sci Rep, 2023, 13(1):13763] | PubMed: 37612452 |
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如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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