Integrin alpha 4 Rabbit Recombinant mAb

生物描述

特异性

Integrin alpha 4 Rabbit Recombinant mAb detects endogenous level of total Integrin alpha 4.

背景

Integrins are a family of 24 heterodimeric cell surface proteins sharing significant structural and functional commonalities. They consist of an alpha- and a beta-chain, which are non-covalently bound. The alpha-chain predominantly defines the ligand specificity of the integrin. Integrin alpha4 is highly expressed in ALL. The integrin alpha4 chain associates with the integrin β1 chain to form very late antigen-4 (VLA4), which binds to its counter receptors vascular cell adhesion molecule (VCAM)-1, fibronectin, or osteopontin, and regulates homing, adhesion, and engraftment of hematopoietic progenitors in BM7 and engraftment of ALL cells.

使用信息

抗体应用	WB, IHC,ELISA,ELISA
稀释比例	WB IHC 1:1000 1:50
反应性	Human
MW (kDa)	150kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Shishido S, et al. Front Oncol. 2014, 4:99. [2] Hsieh YT, et al. Blood. 2013, 121(10):1814-8.

Application Data

WB

IHC