Integrin alpha V Rabbit Recombinant mAb

生物描述

特异性

Integrin alpha V Rabbit Recombinant mAb detects endogenous level of total Integrin alpha V.

背景

Integrins are heterodimeric transmembrane receptors that mediate cell-adhesion. They have been shown to play important roles in embryonic development, wound healing, metastasis, and other biological processes. Integrins are formed through noncovalent association of two type I transmembrane glycoproteins, the α- and the β subunit. αv integrins (αvβ1, αvβ3, αvβ5, αvβ6 and αvβ8) mediate cell adhesion to various matrix proteins including fibronectin, vitronectin, tenascin, osteopontin, and fibrinogen at sites containing the tripeptide sequence arginine-glycine-aspartic acid (RGD). In addition to recognizing distinct subsets of RGD-containing ligands, αv integrins have been reported to exert distinct effects on cell behavior. αvβ5 is widely expressed on epithelial cells including keratinocytes, airway epithelial cells, fibroblasts, osteoclasts, and monocytes. αvβ5 has been suggested to play important roles in activation-dependent cell migration, in promoting adenovirus-mediated gene delivery, and in cutaneous wound healing.

使用信息

抗体应用	WB, IHC, IF,ELISA,ELISA
稀释比例	WB IHC IF 1:1000 1:50 1:50
反应性	Human Mouse Rat
MW (kDa)	26kDa/125kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Erik H. J Danen, et al. Madame Curie Bioscience Database. [2] Xiaozhu Huang, et al. Mol Cell Biol. 2000, 20(3): 755–759.

Application Data

WB

IHC

IF