Datasheet

生物描述

特异性	Integrin beta 1(CD29) Rabbit Recombinant mAb detects endogenous levels of total Integrin beta 1(CD29).
背景	Integrins comprise a group of transmembrane heterodimeric proteins consisting of α and β subunits that drive most of the interactions between cells and the extracellular matrix (ECM). Integrin beta 1 (ITGB1) is aberrantly expressed in human breast carcinoma and contributes to diverse malignant phenotypes, including epithelial-to-mesenchymal transition (EMT). The multiple downstream signaling pathways of β1, including FAK, PI3K and ERK/MAPK, coordinating signaling through receptor tyrosine kinases (RTKs), are involved in the modulation of tumor initiation, progression, and ultimately metastasis.

特异性

Integrin beta 1(CD29) Rabbit Recombinant mAb detects endogenous levels of total Integrin beta 1(CD29).

背景

Integrins comprise a group of transmembrane heterodimeric proteins consisting of α and β subunits that drive most of the interactions between cells and the extracellular matrix (ECM). Integrin beta 1 (ITGB1) is aberrantly expressed in human breast carcinoma and contributes to diverse malignant phenotypes, including epithelial-to-mesenchymal transition (EMT). The multiple downstream signaling pathways of β1, including FAK, PI3K and ERK/MAPK, coordinating signaling through receptor tyrosine kinases (RTKs), are involved in the modulation of tumor initiation, progression, and ultimately metastasis.

使用信息

抗体应用

wb,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human

MW (kDa)

150kDa

抗体类型

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Hou S, et al. Sci Rep. 2016, 6:18430.

Application Data

WB

Validated by Selleck