Interferon gamma Rabbit Recombinant mAb Datasheet

生物描述

特异性	Interferon gamma Rabbit Recombinant mAb detects endogenous level of total Interferon gamma.
背景	The IFN family of cytokines is divided into type I and type II IFNs. IFN-γ is at present the only type II interferon identified and activates a distinct type II receptor. IFN-γ has a multitude of functions, displaying direct antiviral activity as well as a variety of immunomodulatory and inflammatory roles. Specific actions of IFN-γ signaling include: stimulation of antigen presentation through induced expression of Class I and II major histocompatibility complex (MHC) molecules on the surface of macrophages and T-lymphocytes; antigen processing; control of Th1 and Th2 balance; activation of macrophages, T-lymphocytes and NK cells; stimulation of cytokine production in target cells; and recruitment of cells to the site of injury through increased expression of chemokines and adhesion molecules. IFN-γ also influences cellular state including regulation of the rate of proliferation, differentiation and apoptosis. Interferon-γ is a master checkpoint regulator of cytokine-induced differentiation. It decreases cytokine-induced activation of STAT3 while increasing STAT1 signaling. IFN-γ induces internalization of the common cytokine receptor gp130 by activating p38 signaling.

特异性

Interferon gamma Rabbit Recombinant mAb detects endogenous level of total Interferon gamma.

背景

The IFN family of cytokines is divided into type I and type II IFNs. IFN-γ is at present the only type II interferon identified and activates a distinct type II receptor. IFN-γ has a multitude of functions, displaying direct antiviral activity as well as a variety of immunomodulatory and inflammatory roles. Specific actions of IFN-γ signaling include: stimulation of antigen presentation through induced expression of Class I and II major histocompatibility complex (MHC) molecules on the surface of macrophages and T-lymphocytes; antigen processing; control of Th1 and Th2 balance; activation of macrophages, T-lymphocytes and NK cells; stimulation of cytokine production in target cells; and recruitment of cells to the site of injury through increased expression of chemokines and adhesion molecules. IFN-γ also influences cellular state including regulation of the rate of proliferation, differentiation and apoptosis. Interferon-γ is a master checkpoint regulator of cytokine-induced differentiation. It decreases cytokine-induced activation of STAT3 while increasing STAT1 signaling. IFN-γ induces internalization of the common cytokine receptor gp130 by activating p38 signaling.

使用信息

抗体应用

WB ,ELISA,ELISA

稀释比例

WB

1:500

反应性

Human Mouse Rat

MW (kDa)

25kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck