Involucrin Rabbit Recombinant mAb detects endogenous levels of total Involucrin.

lnvolucrin is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. Involucrin is normally not expressed in non-epithelial cells. It is expressed in a range of stratified squamous epithelia, including the cornea which lacks a distinct cornfied layer. The protein is a useful marker of terminal differentiation. It is tightly linked to the onset of differentiation and first expressed in the immediate suprabasal layers of the epidermis.