生物描述

特异性

IQGAP1 Rabbit Recombinant mAb detects endogenous levels of total IQGAP1

背景

The IQGAP family consist of three members, termed IQGAP1, IQGAP2 and IQGAP3. The IQGAPs exhibit some common characteristics, including considerable sequence overlap. Nevertheless, they differ in many aspects, such as function, tissue distribution and subcellular localization. For example, IQGAP1 is ubiquitously expressed, while IQGAP2 is found predominantly in the liver and IQGAP3 expression appears confined to the brain, lung, testis, small intestine and colon. IQGAP1 is an effector for Rac and Cdc42 that contains binding sites for actin, extracellular signal regulated kinase 2 (ERK2), calmodulin, myosin essential light chain, S100B, Rac/Cdc42, β-catenin, E-cadherin, CLIP-170 and adenomatous polyposis coli (APC). It appears to play a pivotal role in the control of cell adhesion, polarization and migration.

使用信息

抗体应用	WB, IHC,ELISA,ELISA
稀释比例	WB IHC 1:1000 1:50
反应性	Human Mouse
MW (kDa)	180kDa
抗体类型
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] White CD, et al. Cell Signal. 2012;24(4):826-34. [2] Noritake J, et al. J Cell Sci. 2005,15;118(Pt 10):2085-92.

Application Data

WB

IHC