Irinotecan hydrochloride

目录号：S5026 批次号：S502601

打印

化学数据

化学结构式 别名 CPT-11 hydrochloride, (+)-Irinotecan hydrochloride 储存条件
(自收到货起)		 3年 -20°C 粉状
化学式

C33H39ClN4O6
分子量 623.14 CAS号 100286-90-6
Solubility (25°C)* 体外 DMSO 100 mg/mL (160.47 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述 Irinotecan (CPT-11, (+)-Irinotecan) hydrochloride 是一种 Topoisomerase I (Topo I) 的抑制剂，对LoVo细胞和HT-29细胞具有细胞毒性，对应的IC50值分别为15.8 μM和5.17 μM。
靶点
Topo I [1] cytotoxicity in HT-29 cells [1]
(Cell-based assay)		 cytotoxicity in LoVo cells [1]
(Cell-based assay)
5.17 μM 15.8 μM

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

Irinotecan hydrochloride在文献中得到引用

Cell membrane-camouflaged bufalin targets NOD2 and overcomes multidrug resistance in pancreatic cancer [ Drug Resist Updat, 2023, 71:101005] PubMed: 37647746
A novel TOX3-WDR5-ABCG2 signaling axis regulates the progression of colorectal cancer by accelerating stem-like traits and chemoresistance [ PLoS Biol, 2023, 21(9):e3002256] PubMed: 37708089
A novel TOX3-WDR5-ABCG2 signaling axis regulates the progression of colorectal cancer by accelerating stem-like traits and chemoresistance [ PLoS Biol, 2023, 21(9):e3002256] PubMed: 37708089
HECW2 promotes the progression and chemoresistance of colorectal cancer via AKT/mTOR signaling activation by mediating the ubiquitin-proteasome degradation of lamin B1 [ J Cancer, 2023, 10.7150/jca.87545] PubMed: 37781079
HECW2 promotes the progression and chemoresistance of colorectal cancer via AKT/mTOR signaling activation by mediating the ubiquitin-proteasome degradation of lamin B1 [ J Cancer, 2023, 14(15):2820-2832] PubMed: 37781079
Colorectal Cancer Patient-Derived 2D and 3D Models Efficiently Recapitulate Inter- and Intratumoral Heterogeneity [ Adv Sci (Weinh), 2022, e2201539] PubMed: 35652270
Inhibition of Heme Export and/or Heme Synthesis Potentiates Metformin Anti-Proliferative Effect on Cancer Cell Lines [ Cancers (Basel), 2022, 14(5)1230] PubMed: 35267538
coupled Hydrodynamic Flow Focusing (cHFF) to Engineer Lipid-Polymer Nanoparticles (LiPoNs) for Multimodal Imaging and Theranostic Applications [ Biomedicines, 2022, 10(2)438] PubMed: 35203647
K-Ras and p53 mouse model with molecular characteristics of human rhabdomyosarcoma and translational applications [ Dis Model Mech, 2022, 15-2dmm049004] PubMed: 35174853
Integrated genome and tissue engineering enables screening of cancer vulnerabilities in physiologically relevant perfusable ex vivo cultures [ Biomaterials, 2021, 280:121276] PubMed: 34890975

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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