ITD-1

目录号:S6713 批次号:S671302

打印

化学数据

化学结构式 别名 N/A 储存条件
(自收到货起)
3年 -20°C 粉状
化学式

C27H29NO3

分子量 415.52 CAS号 1099644-42-4
Solubility (25°C)* 体外 DMSO 83 mg/mL (199.74 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述 ITD-1是有效的TGF-β抑制剂。它不抑制TGFBR1或TGFBR的激酶活性,但能够有效地抑制TGFβ2诱导的效应因子SMAD2/3磷酸化,对Activin A的影响甚微。
靶点
TGF-β [1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

ITD-1在文献中得到引用

Alpha-hederin reprograms multi-miRNAs activity and overcome small extracellular vesicles-mediated paclitaxel resistance in NSCLC [ Front Pharmacol, 2024, 15:1257941] PubMed: 38362150
KIAA1429-mediated m6A modification of CHST11 promotes progression of diffuse large B-cell lymphoma by regulating Hippo-YAP pathway [ Cell Mol Biol Lett, 2023, 28(1):32] PubMed: 37076815
Tripartite motif-containing 9 promoted proliferation and migration of bladder cancer cells through CEACAM6-Smad2/3 axis [ J Cell Commun Signal, 2023, 10.1007/s12079-023-00766-7] PubMed: 37249822
A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling [ Nat Commun, 2022, 13(1):438] PubMed: 35064106
TGF-β induces GBM mesenchymal transition through upregulation of CLDN4 and nuclear translocation to activate TNF-α/NF-κB signal pathway [ Cell Death Dis, 2022, 13(4):339] PubMed: 35418179
HOXA10 mediates epithelial-mesenchymal transition to promote gastric cancer metastasis partly via modulation of TGFB2/Smad/METTL3 signaling axis [ J Exp Clin Cancer Res, 2021, 40(1):62] PubMed: 33563300
Discovery of a novel short peptide with efficacy in accelerating the healing of skin wounds [ Pharmacol Res, 2020, S1043-6618(20)31604-2] PubMed: 33220421
Human induced pluripotent stem cell-derived cardiomyocytes reveal abnormal TGFβ signaling in type 2 diabetes mellitus. [ J Mol Cell Cardiol, 2020, 3;142:53-64] PubMed: 32251671
Transforming growth factor-β1 suppress pentraxin-3 in human orbital fibroblasts. [ Endocrine, 2020, 16] PubMed: 32300954
Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction. [ Nat Commun, 2017, 8:14656] PubMed: 28256515

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。

如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!

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