IWP-2

目录号：S7085 批次号：S708505

化学数据

	别名	N/A	储存条件 (自收到货起)	3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂
	化学式	C₂₂H₁₈N₄O₂S₃
	分子量	466.6	CAS号	686770-61-6
Solubility (25°C)*	体外	DMF warmed with 50ºC water bath	20 mg/mL (42.86 mM)
		DMSO warmed with 50ºC water bath	3 mg/mL (6.42 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

IWP-2是一种Wnt信号和分泌抑制剂，无细胞试验中IC50为27 nM，选择性阻断Porcn介导的Wnt棕榈酰化，一般不影响Wnt/β-catenin，且对Wnt刺激的细胞反应没有影响。IWP-2可特定低抑制 CK1δ。

靶点

Wnt ^[1] (Cell-free assay)	^M82FCK1δ ^[3] (Cell-free assay)
27 nM	40 nM

体外研究

IWP-2在再生医学和抗癌方面都非常有效。IWP-2使Porcn失活, Porcn是一种与O-酰基转移酶(MBOAT)结合的膜,且选择性抑制Wnt棕榈酰化。IWP-2抑制Lrp6受体和Dvl2发生Wnt依赖性的磷酸化，也抑制β-catenin累积。^[1]

参考文献

客户使用selleck产品的实验数据

: 数据来源于[Data independently produced by , , Sci Rep, 2016, 6:32770.]

: 数据来源于[Data independently produced by , , Methods, 2016, 101:103-12.]

: 数据来源于[Data independently produced by , , Biochem Biophys Res Commun, 2017, 486(1):49-56]

IWP-2在文献中得到引用

ETVs dictate hPSC differentiation by tuning biophysical properties [ Nat Commun, 2025, 16(1):1999]	PubMed: 40011454
AAV vectors trigger DNA damage response-dependent pro-inflammatory signalling in human iPSC-derived CNS models and mouse brain [ Nat Commun, 2025, 16(1):3694]	PubMed: 40251179
The balance between IFN-γ and ERK/MAPK signaling activities ensures lifelong maintenance of intestinal stem cells [ Cell Rep, 2025, S2211-1247(25)00057-9]	PubMed: 39952238
Human epicardial organoids from pluripotent stem cells resemble fetal stage with potential cardiomyocyte- transdifferentiation [ Cell Biosci, 2025, 15(1):4]	PubMed: 39825425
Heightened sensitivity to adverse effects of metformin in mtDNA mutant patient cells [ Life Sci, 2025, 366-367:123486]	PubMed: 39978587
Long-term tracking of neural and oligodendroglial development in large-scale human cerebral organoids by noninvasive volumetric imaging [ Sci Rep, 2025, 15(1):2536]	PubMed: 39833280
Interplay of SHH, WNT and BMP4 signaling regulates the development of the lamina propria in the murine ureter [ Development, 2025, 152(3)DEV204214]	PubMed: 39817691
Restoration of excitation/inhibition balance enhances neuronal signal-to-noise ratio and rescues social deficits in autism-associated Scn2a -deficiency [ bioRxiv, 2025, 2025.03.04.641498]	PubMed: 40093153
Human cerebral organoids model tumor infiltration and migration supported by astrocytes in an autologous setting [ bioRxiv, 2025, 2025.01.29.635456]	PubMed: 39974912
A primate-specific endogenous retroviral envelope protein sequesters SFRP2 to regulate human cardiomyocyte development [ Cell Stem Cell, 2024, S1934-5909(24)00256-X]	PubMed: 39146934

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如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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