IWR-1-endo

目录号：S7086 批次号：S708602

化学数据

	别名	endo-IWR 1, IWR-1	储存条件 (自收到货起)	3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂
	化学式	C₂₅H₁₉N₃O₃
	分子量	409.44	CAS号	1127442-82-3
Solubility (25°C)*	体外	DMSO	30 mg/mL (73.27 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

IWR-1-endo (endo-IWR 1, IWR-1)是一种Wnt通路抑制剂，在表达 Wnt3A 的 L-细胞中IC50为180 nM，诱导Axin2蛋白水平，并通过稳定Axin骨架破坏复合体来促进β-catenin磷酸化。

靶点

Wnt ^[1]
(L-cells expressing Wnt3A)

180 nM

体外研究

IWR-1 和XAV939作为Wnt通路的可逆抑制剂，在体内外具有相似的药理作用，IWR-1通过与Axin相互作用而发挥效果,而XAV939直接与TNKS结合。^[1]

参考文献

客户使用selleck产品的实验数据

: 数据来源于[Data independently produced by , , Diabetes, 2018, 67(4):554-568]

: 数据来源于[Data independently produced by , , Biochim Biophys Acta Mol Cell Biol Lipids, 2018, 1863(8):834-843]

: 数据来源于[Data independently produced by , , Am J Cancer Res, 2015, 5(10):3123-3134.]

IWR-1-endo在文献中得到引用

Medium from human iPSC-derived primitive macrophages promotes adult cardiomyocyte proliferation and cardiac regeneration [ Nat Commun, 2025, 16(1):3012]	PubMed: 40148355
Highly efficient construction of monkey blastoid capsules from aged somatic cells [ Nat Commun, 2025, 16(1):1130]	PubMed: 39875393
Intelligent in-cell electrophysiology: Reconstructing intracellular action potentials using a physics-informed deep learning model trained on nanoelectrode array recordings [ Nat Commun, 2025, 16(1):657]	PubMed: 39809732
An FDA-approved drug structurally and phenotypically corrects the K210del mutation in genetic cardiomyopathy models [ J Clin Invest, 2025, 135(4)e174081]	PubMed: 39959972
Disruption of the β-catenin destruction complex via Ephexin1-Axin1 interaction promotes colorectal cancer proliferation [ Exp Mol Med, 2025, 57(1):151-166]	PubMed: 39741188
CircSARS-CV2-N1368 from SARS-CoV-2 impairs endothelial cell function through the upregulation of ATF7 to activate TLR4/NF-κB/ROS signaling [ Acta Pharmacol Sin, 2025, none]	PubMed: 40069492
Adipose-derived stem cells enhance the tumorigenic potential of pre-malignant breast epithelial cells through paracrine activation of PI3K-AKT pathway [ Breast Cancer, 2025, 10.1007/s12282-025-01686-7]	PubMed: 40019720
Human induced pluripotent stem cells derived neutrophils display strong anti-microbial potencies [ Cell Regen, 2025, 14(1):8]	PubMed: 40113653
Protocol for differentiating cardiomyocytes and generating engineered heart tissues from human feeder-free extended pluripotent stem cells [ STAR Protoc, 2025, 6(1):103576]	PubMed: 39893639
Electrically Conductive Collagen-PEDOT:PSS Hydrogel Prevents Post-Infarct Cardiac Arrhythmia and Supports hiPSC-Cardiomyocyte Function [ Adv Mater, 2024, e2403642]	PubMed: 38653478

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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