JAM1 Rabbit Recombinant mAb

生物描述

特异性

JAM1 Rabbit Recombinant mAb detects endogenous level of total JAM1.

背景

Junctional adhesion molecules (JAMs) are members of an immunoglobulin subfamily expressed by leukocytes and platelets as well as by epithelial and endothelial cells, in which they localize to cell-cell contacts and are specifically enriched at tight junctions. JAMs associate through their extracellular domains with the leukocyte β2 integrins LFA-1 and Mac-1 as well as with the β1 integrin α4β1. All three integrins are involved in the regulation of leukocyte-endothelial cell interactions. Through their cytoplasmic domains, JAMs directly associate with various tight junction-associated proteins including ZO-1, AF-6, MUPP1 and the cell polarity protein PAR-3. Junctional adhesion molecule 1 (JAM-1) is a functional receptor for feline calicivirus and also for reovirus, which infects most children and can cause mild gastrointestinal or respiratory illness.

使用信息

抗体应用	WB, IHC,ELISA,ELISA
稀释比例	WB IHC 1:1000 1:50
反应性	Human Mouse Rat
MW (kDa)	33kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Kenneth J. Mandell, et al. The Journal of Biological Chemistry. 2004, 279: 16254-16262. [2] Makino A, et al. J Virol. 2006, 80(9):4482-90. [3] Ebnet K, et al. J Cell Sci. 2004, 117(Pt 1):19-29.

Application Data

WB

IHC