K Cadherin Rabbit Recombinant mAb Datasheet

生物描述

特异性	K Cadherin Rabbit Recombinant mAb detects endogenous level of total K Cadherin.
背景	Cadherins are a family of calcium-dependent, cell-cell adhesion molecules that play an important morphoregulatory role in a wide variety of tissues. Cadherin‑6 (CDH6), also known as KCAD or K-cadherin, is a class II cadherin that is mainly found in the kidney and the CNS and involved in the morphogenesis of central nervous system and kidney. CDH6 controls cellular architecture and dictates the structure of the cell-cell interaction. CDH6 restrains autophagy and promotes DRP1-dependent mitochondrial fission. It is highly expressed during embryonic kidney development, where it promotes mesenchymal-to-epithelial transition (MET). CDH6 is aberrantly reactivated in cancer.

特异性

K Cadherin Rabbit Recombinant mAb detects endogenous level of total K Cadherin.

背景

Cadherins are a family of calcium-dependent, cell-cell adhesion molecules that play an important morphoregulatory role in a wide variety of tissues. Cadherin‑6 (CDH6), also known as KCAD or K-cadherin, is a class II cadherin that is mainly found in the kidney and the CNS and involved in the morphogenesis of central nervous system and kidney. CDH6 controls cellular architecture and dictates the structure of the cell-cell interaction. CDH6 restrains autophagy and promotes DRP1-dependent mitochondrial fission. It is highly expressed during embryonic kidney development, where it promotes mesenchymal-to-epithelial transition (MET). CDH6 is aberrantly reactivated in cancer.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

130kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck