KMT4/Dot1L Rabbit Recombinant mAb Datasheet

生物描述

特异性	KMT4/Dot1L Rabbit Recombinant mAb detects endogenous level of total KMT4/Dot1L.
背景	The H3K79 methyltransferase, DOT1L, is involved in a number of key processes ranging from gene expression to DNA-damage response and cell cycle progression. Dot1/DOT1L catalyzes the sequential mono-, di-, and tri-methylation of H3K79. It is an epigenetic regulator of G1/S progression. At the cellular level, Dot1L deficiency leads to alterations in constitutive heterochromatin, accompanied by telomere elongation, aneuploidy, and proliferation defects. DOT1L has also been implicated in the development of mixed lineage leukemia (MLL)-rearranged leukemia, where mistargeting of DOT1L causes aberrant H3K79 methylation at homeobox genes. Actually, DOT1L controls the development of diseases including leukemia, cardiac dysfunction, and kidney injury, as well as normal cellular processes.

特异性

KMT4/Dot1L Rabbit Recombinant mAb detects endogenous level of total KMT4/Dot1L.

背景

The H3K79 methyltransferase, DOT1L, is involved in a number of key processes ranging from gene expression to DNA-damage response and cell cycle progression. Dot1/DOT1L catalyzes the sequential mono-, di-, and tri-methylation of H3K79. It is an epigenetic regulator of G1/S progression. At the cellular level, Dot1L deficiency leads to alterations in constitutive heterochromatin, accompanied by telomere elongation, aneuploidy, and proliferation defects. DOT1L has also been implicated in the development of mixed lineage leukemia (MLL)-rearranged leukemia, where mistargeting of DOT1L causes aberrant H3K79 methylation at homeobox genes. Actually, DOT1L controls the development of diseases including leukemia, cardiac dysfunction, and kidney injury, as well as normal cellular processes.

使用信息

抗体应用

WB ,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse

MW (kDa)

185kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck