KN-93

目录号：S6787 批次号：S678701

化学数据

	别名	N/A	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₂₆H₂₉ClN₂O₄S
	分子量	501.04	CAS号	139298-40-1
Solubility (25°C)*	体外	DMSO	100 mg/mL (199.58 mM)
		Ethanol	21 mg/mL (41.91 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

KN-93 是一种具有细胞渗透性和竞争性的 Ca2+/calmodulin-dependent protein kinase II (CaMK-II) 的可逆抑制剂，对于兔心肌 CaM 激酶活性的Ki值为2.58 μM。

靶点

CaMKII ^[1]
(Cell-free assay)

2.58 μM(Ki)

参考文献

KN-93在文献中得到引用

CaMK4 controls follicular helper T cell expansion and function during normal and autoimmune T-dependent B cell responses [ Nat Commun, 2024, 15(1):840]	PubMed: 38287012
Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src [ Nat Commun, 2024, 15(1):1300]	PubMed: 38346942
CaMKII regulates the proteins TPM1 and MYOM2 and promotes diacetylmorphine-induced abnormal cardiac rhythms [ Sci Rep, 2023, 13(1):5827]	PubMed: 37037889
Late sodium current in synergism with Ca2+/calmodulin-dependent protein kinase II contributes to β-adrenergic activation-induced atrial fibrillation [ Philos Trans R Soc Lond B Biol Sci, 2023, 378(1879):20220163]	PubMed: 37122215
SGLT2 inhibitor dapagliflozin reduces endothelial dysfunction and microvascular damage during cardiac ischemia/reperfusion injury through normalizing the XO-SERCA2-CaMKII-coffilin pathways [ Theranostics, 2022, 12(11):5034-5050]	PubMed: 35836807
Silica nanoparticles induce cardiac injury and dysfunction via ROS/Ca2+/CaMKII signaling [ Sci Total Environ, 2022, 837:155733]	PubMed: 35526619
Activation of transient receptor potential vanilloid 4 is involved in pressure overload-induced cardiac hypertrophy [ Elife, 2022, 11e74519]	PubMed: 35731090
Ion channel Piezo1 activation promotes aerobic glycolysis in macrophages [ Front Immunol, 2022, 13:976482]	PubMed: 36119083
Effects and potential mechanism of Ca2+/calmodulin‑dependent protein kinase II pathway inhibitor KN93 on the development of ovarian follicle [ Int J Mol Med, 2022, 50(4)121]	PubMed: 35929517
Effect of feeding regimen on circadian activity rhythms of food anticipatory by ghrelin hormone in a pig model [ Nutr Neurosci, 2022, 1-19]	PubMed: 35249475

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如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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