Ku70 Rabbit Recombinant mAb

生物描述

特异性

Ku70 Rabbit Recombinant mAb detects endogenous level of Ku70.

背景

Ku is a nuclear protein identified as an autoantigen. The Ku protein is a complex of two subunits, Ku70 and Ku80. Ku is an abundant, highly conserved DNA binding protein found in both prokaryotes and eukaryotes that plays essential roles in the maintenance of genome integrity and is involved in multiple nuclear processes, e.g., DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. Ku is also associated with telomeres, where, paradoxically to its DNA end-joining functions, it protects the telomere ends from being recognized as DSBs, thereby preventing their recombination and degradation. Ku70 is regarded as a direct inhibitor of apoptosis, through the binding and inhibition of the pro-apoptotic factor Bax.

使用信息

抗体应用	WB, IF,ELISA,ELISA
稀释比例	WB IF 1:1000 1:50
反应性	Human
MW (kDa)	70kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Koike M. J Radiat Res. 2002, 43(3):223-36. [2] Fell VL, et al. Mutat Res Rev Mutat Res. 2015, 763:15-29.

Application Data

WB

IF