Lapatinib ditosylate monohydrate

目录号：S5241 批次号：S524101

化学数据

	别名	Lapatinib ditoluenesulfonate monohydrate, Lapatinib tosilate, Lapatinib tosilate hydrate	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₄₃H₄₄ClFN₄O₁₁S₃
	分子量	943.48	CAS号	388082-78-8
Solubility (25°C)*	体外	DMSO	100 mg/mL (105.99 mM)
		Water	Insoluble

* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述

Lapatinib ditosylate monohydrate (Lapatinib ditoluenesulfonate monohydrate, Lapatinib tosilate, Lapatinib tosilate hydrate) is a dual tyrosine kinase inhibitor which interrupts the HER2/neu and epidermal growth factor receptor (EGFR) pathways, used for treatment of solid tumours such as breast and lung cancer.

靶点

ErbB2 ^[1] (Cell-free assay)	EGFR ^[1] (Cell-free assay)	ErbB4 ^[1] (Cell-free assay)
9.2 nM	10.8 nM	367 nM

参考文献

[1] Rusnak DW, et al. Mol Cancer Ther. 2001, 1(2):85-94.

Lapatinib ditosylate monohydrate在文献中得到引用

HDAC Inhibition Restores Response to HER2-Targeted Therapy in Breast Cancer via PHLDA1 Induction [ Int J Mol Sci, 2023, 24(7)6228]	PubMed: 37047202
Irreversible tyrosine kinase inhibitors induce the endocytosis and downregulation of ErbB2 [ Biochem Biophys Rep, 2023, 34:101436]	PubMed: 36824069
RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy [ Cancer Discov, 2022, 12(1):204-219]	PubMed: 34544753
Proteo-genomic characterization of virus-associated liver cancers reveals potential subtypes and therapeutic targets [ Nat Commun, 2022, 13(1):6481]	PubMed: 36309506
Organoid screening reveals epigenetic vulnerabilities in human colorectal cancer [ Nat Chem Biol, 2022, 10.1038/s41589-022-00984-x]	PubMed: 35273398
Sustained oncogenic signaling in the cytostatic state enables targeting of non-proliferating persistent cancer cells [ Cancer Res, 2022, can.21.2908]	PubMed: 35792658
INHBA is a mediator of aggressive tumor behavior in HER2+ basal breast cancer [ Breast Cancer Res, 2022, 24(1):18]	PubMed: 35248133
RASSF1A independence and early galectin-1 upregulation in PIK3CA-induced hepatocarcinogenesis: new therapeutic venues [ Mol Cancer Ther, 2022, 21(5):751-761]	PubMed: 35417017
HER2 mediates PSMA/mGluR1-driven resistance to the DS-7423 dual PI3K/mTOR inhibitor in PTEN wild-type prostate cancer models [ Mol Cancer Ther, 2022, molcanther.0320.2021]	PubMed: 35086953
Establishment and large-scale validation of a three-dimensional tumor model on an array chip for anticancer drug evaluation [ Front Pharmacol, 2022, 13:1032975]	PubMed: 36313330

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如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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