Leupeptin Hemisulfate

目录号：S7380 批次号：S738018

化学数据

	别名	N/A	储存条件 (自收到货起)	3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂
	化学式	C₂₀H₃₈N₆O₄.1/2H₂SO₄
	分子量	475.59	CAS号	103476-89-7
Solubility (25°C)*	体外	DMSO	95 mg/mL (199.75 mM)
		Water	95 mg/mL (199.75 mM)
		Ethanol	95 mg/mL (199.75 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

Leupeptin Hemisulfate是溶酶体丝氨酸蛋白酶和半胱氨酸蛋白酶可逆的抑制剂。抑制cathepsin B(Ki=6 nM), calpain(Ki=10 nM), trypsin (Ki=35 nM), plasmin (Ki=3.4 μM)和kallikrein (Ki=19 μM)，对chymotrypsin, elastase, renin,或pepsin没有作用。

靶点

Cysteine protease ^[1]

serine protease ^[1]

体外研究

Leupeptin，由不同种类的放线菌产生，强烈抑制蛋白质的水解作用。^[1]

Leupeptin hemisulfate保护微管蛋白在分离过程中免受内源性蛋白质水解酶的破坏，并使微管蛋白纯度增加。^[2]

Leupeptin hemisulfate能够恢复细胞悬浮培养液中高达50%的乙型肝炎表面抗原(HBsAg)的表达。^[3]

参考文献

[4] Haspel J, et al. Autophagy. 2011 Jun;7(6):629-42.

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Leupeptin Hemisulfate在文献中得到引用

FOXS1, frequently inactivated by promoter methylation, inhibited colorectal cancer cell growth by promoting TGFBI degradation through autophagy-lysosome pathway [ J Adv Res, 2025, S2090-1232(25)00056-6]	PubMed: 39864590
Targeting deubiquitinase USP7-mediated stabilization of XPO1 contributes to the anti-myeloma effects of selinexor [ J Transl Med, 2025, 23(1):62]	PubMed: 39806439
Hepatic Lamp2a deficiency promotes inflammation of murine autoimmune cholangitis via affecting bile acid metabolism [ iScience, 2025, 28(2):111804]	PubMed: 39995863
Bafilomycin A1 induces colon cancer cell death through impairment of the endolysosome system dependent on iron [ Sci Rep, 2025, 15(1):5148]	PubMed: 39934167
ARIH1 activates STING-mediated T-cell activation and sensitizes tumors to immune checkpoint blockade [ Nat Commun, 2023, 14(1):4066]	PubMed: 37429863
Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy-lysosomal pathway [ Acta Pharm Sin B, 2022, 12(6):2869-2886]	PubMed: 35755273
18F-FDG PET as an imaging biomarker for the response to FGFR-targeted therapy of cancer cells via FGFR-initiated mTOR/HK2 axis [ Theranostics, 2022, 12(14):6395-6408]	PubMed: 36168616
CLP36 promotes p53 deficient sarcoma progression through suppression of atrophin-1 interacting protein-4 (AIP-4)-dependent degradation of YAP1 [ Theranostics, 2022, 12(11):5051-5068]	PubMed: 35836803
Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription [ Cell Rep, 2022, 38(4):110302]	PubMed: 35081346
Histone deacetylase 3 facilitates TNFα-mediated NF-κB activation through suppressing CTSB induced RIP1 degradation and is required for host defense against bacterial infection [ Cell Biosci, 2022, 12(1):81]	PubMed: 35658939

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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