Datasheet

生物描述

特异性	LOXL2 Rabbit Recombinant mAb detects endogenous levels of total LOXL2.
背景	LOX-like (LOXL)2 is a member of the lysyl oxidase (LOX) family, which is comprised of five members, the prototypical LOX and four related members, LOXL1-4. It is a secreted copper-dependent amine oxidase, and its main role is to catalyze the covalent cross-link of collagen and elastin in the extracellular matrix (ECM). LOXL2 may be a tumor suppressor and promotes invasion and metastasis in cancer. It plays a dual role in EMT induction. First, it interacts with and stabilizes Snail1, promoting CDH1 silencing and, thus, inducing EMT. Second, LOXL2 helps to maintain the mesenchymal phenotype due, at least in part, to downregulation of cell polarity and epidermal differentiation genes in a Snail1-independent fashion, associated to activation of FAK kinase.

特异性

LOXL2 Rabbit Recombinant mAb detects endogenous levels of total LOXL2.

背景

LOX-like (LOXL)2 is a member of the lysyl oxidase (LOX) family, which is comprised of five members, the prototypical LOX and four related members, LOXL1-4. It is a secreted copper-dependent amine oxidase, and its main role is to catalyze the covalent cross-link of collagen and elastin in the extracellular matrix (ECM). LOXL2 may be a tumor suppressor and promotes invasion and metastasis in cancer. It plays a dual role in EMT induction. First, it interacts with and stabilizes Snail1, promoting CDH1 silencing and, thus, inducing EMT. Second, LOXL2 helps to maintain the mesenchymal phenotype due, at least in part, to downregulation of cell polarity and epidermal differentiation genes in a Snail1-independent fashion, associated to activation of FAK kinase.

使用信息

抗体应用

wb,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

53,106kDa

抗体类型

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck