LXR alpha Rabbit Recombinant mAb Datasheet

生物描述

特异性	LXR alpha Rabbit Recombinant mAb detects endogenous level of total LXR alpha.
背景	Liver X receptor (LXR) α and LXRβ are closely related nuclear receptors that respond to elevated levels of intracellular cholesterol by enhancing transcription of genes that control cholesterol efflux and fatty acid biosynthesis. Both liver X receptor (LXR) subtypes are activated by multiple oxysterols. In addition to their well-established function as regulators of cholesterol and fatty acid metabolism, more recent evidence points to additional roles for the LXR nuclear receptors in inflammation, glucose metabolism and fertility. It has been reported that separate activation of LXRα and LXRβ yields distinctive lipid outcomes in vivo.

特异性

LXR alpha Rabbit Recombinant mAb detects endogenous level of total LXR alpha.

背景

Liver X receptor (LXR) α and LXRβ are closely related nuclear receptors that respond to elevated levels of intracellular cholesterol by enhancing transcription of genes that control cholesterol efflux and fatty acid biosynthesis. Both liver X receptor (LXR) subtypes are activated by multiple oxysterols. In addition to their well-established function as regulators of cholesterol and fatty acid metabolism, more recent evidence points to additional roles for the LXR nuclear receptors in inflammation, glucose metabolism and fertility. It has been reported that separate activation of LXRα and LXRβ yields distinctive lipid outcomes in vivo.

使用信息

抗体应用

WB, IHC,ELISA,ELISA

稀释比例

WB	IHC
1:1000	1:50

反应性

Human Mouse Rat

MW (kDa)

50kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Lund EG, et al. Biochem Pharmacol. 2006, 71(4):453-63.

Application Data

WB

Validated by Selleck

IHC

Validated by Selleck