MCC950

目录号：S8930 批次号：S893001

化学数据

	别名	CP-456773, CRID3	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₂₀H₂₄N₂O₅S
	分子量	404.48	CAS号	210826-40-7
Solubility (25°C)*	体外	DMSO	81 mg/mL (200.25 mM)
		Ethanol	3 mg/mL (7.41 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述

MCC950 (CP-456773, CRID3) 是一种有效的 NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) 的选择性抑制剂，在BMDMs和HMDMs中对应的IC50值分别为7.5 nM和8.1 nM。

靶点

NLRP3 ^[1] (BMDM-based assay)	NLRP3 ^[1] (HMDM-based assay)
7.5 nM	8.1 nM

参考文献

MCC950在文献中得到引用

LL37 complexed to double-stranded RNA induces RIG-I-like receptor signalling and Gasdermin E activation facilitating IL-36γ release from keratinocytes [ Cell Death Dis, 2025, 16(1):198]	PubMed: 40121229
A small molecule directly targets NLRP3 to promote inflammasome activation and antitumor immunity [ Cell Death Dis, 2025, 16(1):252]	PubMed: 40185713
H3K18 lactylation-mediated SIX1 upregulation contributes to silica-induced epithelial-mesenchymal transition in airway epithelial cells [ Toxicology, 2025, 514:154109]	PubMed: 40049282
Progranulin Plays a Protective Role in Pneumococcal Meningitis by Inhibiting Pyroptosis [ Immun Inflamm Dis, 2025, 13(2):e70140]	PubMed: 39887961
cGAS/STING/NLRP3 Signaling Pathway-Mediated Pyroptosis in Hypertrophic Cardiomyopathy Radiotherapy [ Front Biosci (Landmark Ed), 2025, 30(3):26084]	PubMed: 40152382
Electroacupuncture Inhibits NLRP3-Mediated Microglial Pyroptosis to Ameliorate Chronic Neuropathic Pain in Rats [ J Pain Res, 2025, 18:1115-1129]	PubMed: 40070891
Breast cancer-derived CAV1 promotes lung metastasis by regulating integrin α6β4 and the recruitment and polarization of tumor-associated neutrophils [ Int J Biol Sci, 2024, 20(14):5695-5714]	PubMed: 39494337
METTL14 contributes to acute lung injury by stabilizing NLRP3 expression in an IGF2BP2-dependent manner [ Cell Death Dis, 2024, 15(1):43]	PubMed: 38218935
Nuclear receptor Rev-erbα alleviates intervertebral disc degeneration by recruiting NCoR-HDAC3 co-repressor and inhibiting NLRP3 inflammasome [ Cell Prolif, 2024, e13720.]	PubMed: 39045886
Exosomes from Adipose-Derived Mesenchymal Stromal Cells Prevent Medication-Related Osteonecrosis of the Jaw by Inhibiting Macrophage M1 Polarization and Pyroptosis [ Int J Nanomedicine, 2024, 19:12675-12693]	PubMed: 39619056

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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