Datasheet

生物描述

特异性	MEIS1 Rabbit Recombinant mAb detects endogenous levels of total MEIS1.
背景	Meis1, a TALE family homeodomain transcription factor involved in numerous embryonic developmental processes, is selectively expressed in hematopoietic stem/progenitor cells. Meis1 functions as a DNA-binding cofactor of Hox proteins through interaction with Pbx, a member of another TALE homeodomain subfamily of transcription factors. Meis1 cooperates with Hoxa9 to significantly accelerate Hox-induced leukemogenesis. Moreover, Meis1 as well as Hoxa9 have been shown to be the most critical downstream targets of Mixed Lineage Leukemia (MLL) fusion proteins, and their co-expression is sufficient to induce acute myeloid leukemia, recapitulating MLL-ENL-induced immortalization of myeloid progenitor cells. In addition, Meis1 regulates the differentiation arrest, cycling activity and self-renewal of MLL leukemia cells, a critical rate-limiting determinant for establishing leukemia stem cell potential. Meis1 also functions in maintaining long-term hematopoiesis via regulating the cell cycle status of HSC/HPCs.

特异性

MEIS1 Rabbit Recombinant mAb detects endogenous levels of total MEIS1.

背景

Meis1, a TALE family homeodomain transcription factor involved in numerous embryonic developmental processes, is selectively expressed in hematopoietic stem/progenitor cells. Meis1 functions as a DNA-binding cofactor of Hox proteins through interaction with Pbx, a member of another TALE homeodomain subfamily of transcription factors. Meis1 cooperates with Hoxa9 to significantly accelerate Hox-induced leukemogenesis. Moreover, Meis1 as well as Hoxa9 have been shown to be the most critical downstream targets of Mixed Lineage Leukemia (MLL) fusion proteins, and their co-expression is sufficient to induce acute myeloid leukemia, recapitulating MLL-ENL-induced immortalization of myeloid progenitor cells. In addition, Meis1 regulates the differentiation arrest, cycling activity and self-renewal of MLL leukemia cells, a critical rate-limiting determinant for establishing leukemia stem cell potential. Meis1 also functions in maintaining long-term hematopoiesis via regulating the cell cycle status of HSC/HPCs.

使用信息

抗体应用

wb,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

47kDa

抗体类型

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Ariki R, et al. PLoS One. 2014, 9(2):e87646.

Application Data

WB

Validated by Selleck