Menin Rabbit Recombinant mAb Datasheet

生物描述

特异性	Menin Rabbit Recombinant mAb detects endogenous level of total Menin.
背景	Menin is an orphan protein mutated in an inherited tumor syndrome. It acts as a tumor suppressor in endocrine organs and required for leukemic transformation in mouse models. Menin possesses these dichotomous functions probably because it can both positively and negatively regulate gene expression, as well as interact with a multitude of proteins with diverse functions. Although menin is ubiquitously expressed in various organs during mouse embryonic development, its function is tissue-specific; sometimes displaying opposing roles between different organs. For instance, it suppresses tumorigenesis in endocrine organs, yet is essential for leukemogenesis.

特异性

Menin Rabbit Recombinant mAb detects endogenous level of total Menin.

背景

Menin is an orphan protein mutated in an inherited tumor syndrome. It acts as a tumor suppressor in endocrine organs and required for leukemic transformation in mouse models. Menin possesses these dichotomous functions probably because it can both positively and negatively regulate gene expression, as well as interact with a multitude of proteins with diverse functions. Although menin is ubiquitously expressed in various organs during mouse embryonic development, its function is tissue-specific; sometimes displaying opposing roles between different organs. For instance, it suppresses tumorigenesis in endocrine organs, yet is essential for leukemogenesis.

使用信息

抗体应用

WB, IF,ELISA,ELISA

稀释比例

WB	IF
1:1000	1:50

反应性

Human

MW (kDa)

68kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Matkar S, et al. Trends Biochem Sci. 2013, 38(8):394-402.

Application Data

WB

Validated by Selleck

IF

Validated by Selleck