MerTK Rabbit Recombinant mAb Datasheet

生物描述

特异性	MerTK Rabbit Recombinant mAb detects endogenous level of total MerTK.
背景	MERTK (receptor tyrosine kinase Mer) is a receptor tyrosine kinase of the TAM (Tyro3, Axl, MERTK) family and has an important role in the homeostatic, phagocytic clearance of apoptotic cells. Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. It also functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis and plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

特异性

MerTK Rabbit Recombinant mAb detects endogenous level of total MerTK.

背景

MERTK (receptor tyrosine kinase Mer) is a receptor tyrosine kinase of the TAM (Tyro3, Axl, MERTK) family and has an important role in the homeostatic, phagocytic clearance of apoptotic cells. Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. It also functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis and plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

使用信息

抗体应用

WB ,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human

MW (kDa)

188kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck