Metformin

目录号：S5958 批次号：S595803

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化学数据

化学结构式 别名 1,1-Dimethylbiguanide 储存条件
(自收到货起)		 3年 -20°C 粉状
化学式

C4H11N5
分子量 129.16 CAS号 657-24-9
Solubility (25°C)* 体外 DMSO 26 mg/mL (201.3 mM)
Water 26 mg/mL (201.3 mM)
Ethanol 13 mg/mL (100.65 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述 Metformin (1,1-Dimethylbiguanide) 是一种广泛用于治疗2型糖尿病的药物，可激活肝细胞中的 AMP-activated protein kinase (AMPK)。Metformin 可促进单核细胞中的线粒体自噬。Metformin 可通过激活 JNK/p38 MAPK 途径和GADD153来诱导肺癌细胞凋亡。
靶点
AMPK [1] JNK [3] p38 MAPK [3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

Metformin在文献中得到引用

Pump-Less, Recirculating Organ-On-Chip (rOoC) Platform To Model The Metabolic Crosstalk Between Islets and Liver [ Adv Healthc Mater, 2024, e2303785.] PubMed: 38221504
A novel direct adenosine monophosphate kinase activator ameliorates disease progression in preclinical models of Autosomal Dominant Polycystic Kidney Disease [ Kidney Int, 2023, 103(5):917-929] PubMed: 36804411
Metformin suppresses cardiac fibroblast proliferation under high-glucose conditions via regulating the mitochondrial complex I protein Grim-19 involved in the Sirt1/Stat3 signaling pathway [ Free Radic Biol Med, 2023, 206:1-12] PubMed: 37353174
AMPK activator decelerates osteoarthritis development by inhibition of β-catenin signaling in chondrocytes [ J Orthop Translat, 2023, 38:158-166] PubMed: 36439631
Resistin secreted by porcine alveolar macrophages leads to endothelial cell dysfunction during Haemophilus parasuis infection [ Virulence, 2023, 14(1):2171636] PubMed: 36694280
Resveratrol Upregulates Senescence Marker Protein 30 by Activating AMPK/Sirt1-Foxo1 Signals and Attenuating H2O2-Induced Damage in FAO Rat Liver Cells [ J Nutr Sci Vitaminol (Tokyo), 2023, 10.3177/jnsv.69.388] PubMed: 37940580
The NCF1 variant p.R90H aggravates autoimmunity by facilitating the activation of plasmacytoid dendritic cells [ The Journal of Clinical Investigation, 2022-, 132(16)] PubMed: None
Integrative analysis of drug response and clinical outcome in acute myeloid leukemia [ Cancer Cell, 2022, S1535-6108(22)00312-9] PubMed: 35868306
Disrupting metformin adaptation of liver cancer cells by targeting the TOMM34/ATP5B axis [ EMBO Mol Med, 2022, 14(12):e16082] PubMed: 36321555
Hepatic Leptin Signaling Improves Hyperglycemia by Stimulating MAPK Phosphatase-3 Protein Degradation via STAT3 [ Cell Mol Gastroenterol Hepatol, 2022, S2352-345X(22)00168-0] PubMed: 35863745

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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