Methotrexate disodium

目录号：S5097 批次号：S509701

化学数据

	别名	Amethopterin disodium; CL14377 disodium; WR19039 disodium	储存条件 (自收到货起)	3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂
	化学式	C₂₀H₂₀N₈O₅.2Na
	分子量	498.4	CAS号	7413-34-5
Solubility (25°C)*	体外	Water	99 mg/mL (198.63 mM)
		DMSO	Insoluble

* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

Methotrexate sodium是一种叶酸类似物，是细菌、癌细胞和正常细胞中dihydrofolate reductase(DHFR)的非选择性抑制剂，与DHFR、NADPH形成无活性的三元复合物。Methotrexate (MTX)可诱导凋亡。

靶点

hDHFR ^[4]
(Activated peripheral T cells)

24 nM

参考文献

[4] Bennett BC, et al. J Med Chem. 2007, 50(18):4374-81.

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Methotrexate disodium在文献中得到引用

Oncogenic β-catenin-driven liver cancer is susceptible to methotrexate-mediated disruption of nucleotide synthesis [ Chin Med J (Engl), 2023, 10.1097/CM9.0000000000002816]	PubMed: 37612257
Modulation of Skin Inflammatory Responses by Aluminum Adjuvant [ Pharmaceutics, 2023, 15(2)576]	PubMed: 36839900
Multi-omics analysis based on 3D-bioprinted models innovates therapeutic target discovery of osteosarcoma [ Bioact Mater, 2022, 18:459-470]	PubMed: 35415297
Metabolic control of CD47 expression through LAT2-mediated amino acid uptake promotes tumor immune evasion [ Nat Commun, 2022, 13(1):6308]	PubMed: 36274066
Hydroxychloroquine lowers Alzheimer's disease and related dementias risk and rescues molecular phenotypes related to Alzheimer's disease [ Mol Psychiatry, 2022, none]	PubMed: 36577843
Addressing Doxorubicin Resistance in Bone Sarcomas Using Novel Drug-Resistant Models [ Int J Mol Sci, 2022, 23(12)6425]	PubMed: 35742867
Lectin galactoside-binding soluble 3 binding protein mediates methotrexate resistance in choriocarcinoma cell lines [ Bioengineered, 2022, 13(2):2076-2086]	PubMed: 35038949
A network-based approach to integrate nutrient microenvironment in the prediction of synthetic lethality in cancer metabolism [ PLoS Comput Biol, 2022, 18(3):e1009395]	PubMed: 35286311
A study of protein-drug interaction based on solvent-induced protein aggregation by fluorescence correlation spectroscopy [ Analyst, 2022, 10.1039/d2an00031h]	PubMed: 35253833
The novel mechanism of Med12-mediated drug resistance in a TGFBR2-independent manner [ Biochem Biophys Res Commun, 2022, 610:1-7]	PubMed: 35461070

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如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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