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别名 | Amethopterin disodium; CL14377 disodium; WR19039 disodium | 储存条件 (自收到货起) |
3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂 |
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化学式 | C20H20N8O5.2Na |
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分子量 | 498.4 | CAS号 | 7413-34-5 | |
Solubility (25°C)* | 体外 | Water | 100 mg/mL (200.64 mM) | |
DMSO | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | Methotrexate sodium是一种叶酸类似物,是细菌、癌细胞和正常细胞中dihydrofolate reductase(DHFR)的非选择性抑制剂,与DHFR、NADPH形成无活性的三元复合物。Methotrexate (MTX)可诱导凋亡。 | ||
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靶点 |
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Oncogenic β-catenin-driven liver cancer is susceptible to methotrexate-mediated disruption of nucleotide synthesis [ Chin Med J (Engl), 2023, 10.1097/CM9.0000000000002816] | PubMed: 37612257 |
Modulation of Skin Inflammatory Responses by Aluminum Adjuvant [ Pharmaceutics, 2023, 15(2)576] | PubMed: 36839900 |
Multi-omics analysis based on 3D-bioprinted models innovates therapeutic target discovery of osteosarcoma [ Bioact Mater, 2022, 18:459-470] | PubMed: 35415297 |
Metabolic control of CD47 expression through LAT2-mediated amino acid uptake promotes tumor immune evasion [ Nat Commun, 2022, 13(1):6308] | PubMed: 36274066 |
Hydroxychloroquine lowers Alzheimer's disease and related dementias risk and rescues molecular phenotypes related to Alzheimer's disease [ Mol Psychiatry, 2022, none] | PubMed: 36577843 |
Addressing Doxorubicin Resistance in Bone Sarcomas Using Novel Drug-Resistant Models [ Int J Mol Sci, 2022, 23(12)6425] | PubMed: 35742867 |
Lectin galactoside-binding soluble 3 binding protein mediates methotrexate resistance in choriocarcinoma cell lines [ Bioengineered, 2022, 13(2):2076-2086] | PubMed: 35038949 |
A network-based approach to integrate nutrient microenvironment in the prediction of synthetic lethality in cancer metabolism [ PLoS Comput Biol, 2022, 18(3):e1009395] | PubMed: 35286311 |
A study of protein-drug interaction based on solvent-induced protein aggregation by fluorescence correlation spectroscopy [ Analyst, 2022, 10.1039/d2an00031h] | PubMed: 35253833 |
The novel mechanism of Med12-mediated drug resistance in a TGFBR2-independent manner [ Biochem Biophys Res Commun, 2022, 610:1-7] | PubMed: 35461070 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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