生物描述

特异性

MHC class I Rabbit Recombinant mAb detects endogenous levels of total MHC class I.

背景

MHC class I molecules are one of two primary classes of major histocompatibility complex (MHC) molecules expressed on the cell surface of all nucleated cells and present peptide fragments derived from intracellular proteins. These peptides are normally derived from the cell's own ‘house-keeping’ proteins but in a virally infected cell, peptides derived from viral proteins may also be presented. Virus specific cytotoxic T lymphocytes (CTL) monitor cell surface MHC class I molecules for peptides derived from viral proteins and eliminate infected cells. MHC class I molecules fold and assemble within the endoplasmic reticulum (ER) lumen and peptide binding is an integral part of the assembly process. All the MHC class I and class II molecules can present peptides to T cells, but each protein binds a different range of peptides.the presence of several different genes of each MHC class means that any one individual is equipped to present a much broader range of peptides than if only one MHC molecule of each class were expressed at the cell surface.

使用信息

抗体应用	WB, IHC,ELISA,ELISA
稀释比例	WB IHC 1:500 1:50
反应性	Human
MW (kDa)	41kDa
抗体类型
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Eric W Hewitt. Immunology. 2003, 110(2): 163–169. [2] Janeway CA Jr, et al. Immunobiology: The Immune System in Health and Disease. 5th edition. New York: Garland Science; 2001. The major histocompatibility complex and its functions.

Application Data

WB

IHC