Mito-TEMPO

目录号：S9733 批次号：S973301

化学数据

	别名	N/A	储存条件 (自收到货起)	3年 -20°C 粉末（密封）
	化学式	C₂₉H₃₅N₂O₂P^.Cl
	分子量	510.03	CAS号	1334850-99-5
Solubility (25°C)*	体外	DMSO	100 mg/mL (196.06 mM)
		Water	100 mg/mL (196.06 mM)
		Ethanol	100 mg/mL (196.06 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述

Mito-TEMPO (MT) 是一种线粒体靶向超氧化物歧化酶模拟物，通过抑制过氧亚硝酸盐的形成，保护对乙酰氨基酚(APAP)肝毒性的早期阶段。Mito-TEMPO 处理可抑制 APAP 诱导的 RIP3 kinase 表达。

靶点

RIP3 kinase ^[1]

参考文献

Mito-TEMPO在文献中得到引用

Gonococcal OMV-delivered PorB induces epithelial cell mitophagy [ Nat Commun, 2024, 15(1):1669]	PubMed: 38396029
Nucleus pulposus cells regulate macrophages in degenerated intervertebral discs via the integrated stress response-mediated CCL2/7-CCR2 signaling pathway [ Exp Mol Med, 2024, 56(2):408-421.]	PubMed: 38316963
C5b-9 promotes ferritinophagy leading to ferroptosis in renal tubular epithelial cells of trichloroethylene-sensitized mice [ Sci Total Environ, 2024, 923:171378]	PubMed: 38447712
Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling [ Cell Mol Life Sci, 2024, 81(1):88]	PubMed: 38349408
Loss of Myo19 increases metastasis by enhancing microenvironmental ROS gradient and chemotaxis [ EMBO Rep, 2024, 10.1038/s44319-023-00052-y]	PubMed: 38279020
Tumor cell-intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling [ Sci Adv, 2024, 10(3):eadi2012]	PubMed: 38241371
Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma [ Redox Biol, 2023, 62:102687]	PubMed: 36989574
Metabolic reprogramming induced by DCA enhances cisplatin sensitivity through increasing mitochondrial oxidative stress in cholangiocarcinoma [ Front Pharmacol, 2023, 14:1128312]	PubMed: 37818192
Metabolic reprogramming induced by DCA enhances cisplatin sensitivity through increasing mitochondrial oxidative stress in cholangiocarcinoma [ Front Pharmacol, 2023, 14:1128312]	PubMed: 37818192
Targeting Wnt/β-Catenin Signaling Exacerbates Ferroptosis and Increases the Efficacy of Melanoma Immunotherapy via the Regulation of MITF [ Cells, 2022, 11(22)3580]	PubMed: 36429010

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如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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