ML162

目录号：S4452 批次号：S445203

化学数据

	别名	N/A	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₂₃H₂₂Cl₂N₂O₃S
	分子量	477.40	CAS号	1035072-16-2
Solubility (25°C)*	体外	DMSO	95 mg/mL (198.99 mM)
		Ethanol	24 mg/mL (50.27 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

ML162 是一种细胞磷脂 glutathione peroxidase (GPX-4) 的共价抑制剂，可诱导铁死亡。

靶点

GPX-4 ^[1]

参考文献

ML162在文献中得到引用

Dysregulation of mitochondrial α-ketoglutarate dehydrogenase leads to elevated lipid peroxidation in CHCHD2-linked Parkinson's disease models [ Nat Commun, 2025, 16(1):1982]	PubMed: 40011434
SCARB1 links cholesterol metabolism-mediated ferroptosis inhibition to radioresistance in tumor cells [ J Adv Res, 2025, S2090-1232(25)00045-1]	PubMed: 39832721
Ferroptosis-like cell death promotes and prolongs inflammation in Drosophila [ Nat Cell Biol, 2024, 10.1038/s41556-024-01450-7]	PubMed: 38918597
PRMT6-mediated ADMA promotes p62 phase separation to form a negative feedback loop in ferroptosis [ Theranostics, 2024, 14(10):4090-4106]	PubMed: 38994016
The mevalonate pathway contributes to breast primary tumorigenesis and lung metastasis [ Mol Oncol, 2024, 10.1002/1878-0261.13716]	PubMed: 39119789
ZEB2 drives intra-tumor heterogeneity and skin squamous cell carcinoma formation with distinct EMP transition states [ iScience, 2024, 27(11):111169]	PubMed: 39555401
Mutant p53 protects triple-negative breast adenocarcinomas from ferroptosis in vivo [ Sci Adv, 2024, 10(7):eadk1835]	PubMed: 38354236
Buffering of nuclear membrane tension and mechanotransduction by the endoplasmic reticulum revealed by quantitative ALPIN imaging [ Res Sq, 2024, rs.3.rs-5530637]	PubMed: 39711539
ATF3/SPI1/SLC31A1 Signaling Promotes Cuproptosis Induced by Advanced Glycosylation End Products in Diabetic Myocardial Injury [ Int J Mol Sci, 2023, 24(2)1667]	PubMed: 36675183
Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy [ Cell Metab, 2022, S1550-4131-2200411-9]	PubMed: 36257316

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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