Datasheet

生物描述

特异性	MMP13 Rabbit Recombinant mAb detects endogenous levels of total MMP13.
背景	Collagenase-3 (MMP13), a member of the matrix metalloproteinase (MMP) family of neutral endopeptidases, is expressed in the skeleton during embryonic development and is highly overexpressed in human carcinomas and in chondrocytes and synovial cells in rheumatoid arthritis and osteoarthritis. MMP13 is a downstream target of parathyroid hormone (PTH)-related protein (PTHrP) and the transcription factor Osf2/Cbfa1/Runx2 in growth plate chondrocytes. MMP13 also plays a crucial role in the modulation of extracellular matrix degradation and cell-matrix interactions involved in metastasis.

特异性

MMP13 Rabbit Recombinant mAb detects endogenous levels of total MMP13.

背景

Collagenase-3 (MMP13), a member of the matrix metalloproteinase (MMP) family of neutral endopeptidases, is expressed in the skeleton during embryonic development and is highly overexpressed in human carcinomas and in chondrocytes and synovial cells in rheumatoid arthritis and osteoarthritis. MMP13 is a downstream target of parathyroid hormone (PTH)-related protein (PTHrP) and the transcription factor Osf2/Cbfa1/Runx2 in growth plate chondrocytes. MMP13 also plays a crucial role in the modulation of extracellular matrix degradation and cell-matrix interactions involved in metastasis.

使用信息

抗体应用

wb,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse

MW (kDa)

54kDa

抗体类型

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck